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Reproductive Biology

Code 13528
Year 1
Semester S2
ECTS Credits 6
Workload TP(60H)
Scientific area Biomedical Sciences
Entry requirements Not appliable
Mode of delivery Face-to-face
Work placements Not appliable
Learning outcomes This course aims to deepen the student knowledge of reproductive biology in the context of the current development of the area
At the end of UC students should be able to:
-Explain the different aspects of human reproductive biology
-Apply the acquired knowledge solving problems
-Demonstrate critical thinking
-Demonstrate ability to work in a team
-Analyze and discuss scientific articles in English
-Perform experimental procedures in cell culture and molecular biology laboratories
-Use bioinformatic tools for analysis of RNA and protein sequences in practical contexts
-Retrieve and organize scientific information
-Plann an experimental protocol
-Write a scientific project independently, present and discuss it orally in Portuguese
Syllabus OVARIAN AND MENSTRUAL CYCLE
1. Oogenesis
2. Ovarian endocrinology
3. Menstrual cycle
TESTICULAR FUNCTION
1. Spermatogenesis
2. Sertoli cells
3. Hormonal control
4. Other factors
PUBERTY AND REPRODUCTIVE SYSTEM SENESCENCE
1. "Timing" of Puberty
2. Changes of Puberty
3. Molecular mechanisms of Puberty
4. Andropause
5. Menopause
FERTILIZATION
1. Physiology of semen
2. Fertilization
3. Implantation and placenta
ASSISTED REPRODUCTION AND INFERTILITY
1. Infertility and subfertility in male and female
2. Extrinsic factors on the basis of infertility
3. Assisted reproductive techniques
4. The role of stem cells

PRACTICE
-Isolation and culture of rat Sertoli cells
-Expression of molecular markers of Sertoli cells
-Bioinformatics analysis of the androgen receptor mRNA and protein structure
-Estrogen receptor expression in the testis
-Development of a mini-research project
Main Bibliography BOOKS
Jones RE et al (2006). Human Reproductive Biology. ISBN-10: 0120884658

PAPERS
Carreau S et al (2010). Philos Trans R Soc Lond B Biol Sci. 365(1546):1517-35
Colledge WH et al (2010). Mol Cell Endocrinol 324 (1-2): 12–20
Hamada A et al. (2011) The Open Reproductive Science Journal, 3, 27-41
Ikawa M et al (2010). J Clin Invest. 120 (4):984-94
Laurentino S et al (2009). Syst Biol Reprod Med. 55 (4): 137-44
Laurentino S et al (2012) Mol Hum Rep 18(4): 161-170
O’Shaughnessy et al (2009). Mol. Cell. Endocrinol. 306: 2–8
Reddy et al (2009). Trends Endocrinol and Metab 21 (2): 96-103
Sharpe RM et al (2003). Reproduction 125, 769–784
Toppari J et al (2010) Mol Cell Endocrinol. 324 (1-2):39-44
Tsafriri A et al S (2007) Trends Endocrinol and Metab 18 (8): 321-328
Walters KA et al (2008) Biol Rep. 78: 380–389
Zhou X (2010). J Androl. 31 (3):235-43
Teaching Methodologies and Assessment Criteria The teaching/learning activities are theoretical-practical and will be developed through the application of different methodologies: 1. The lectures start with tutor based expository sessions that are followed by practical laboratory works or by the discussion of scientific articles 2. Analysis of physiological cases: students identify the problem and define learning strategies for case resolution 3. Session of oral presentations and discussion of mini research projects (Workshop). In all methodologies students develop activities in small working groups and after an intragroup-discussion, the discussion is broaden between to all groups and tutor.
Sessions will given in classrooms, whenever possible. Alternativelly, attendence will be online using videoconference systems.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2020-05-11

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