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Adriana Oliveira dos Santos

Professor/a Auxiliar

Sector — Cargos/Funções

Departamento de Ciências Médicas Docente do Departamento de Ciências Médicas

CICS - Centro de Investigação em Ciências da Saúde Investigador/a

Publicações Científicas Mais Recentes


(Informação importada da plataforma CiênciaVitae)

    Artigo em revista/Journal article

    1. Francisco Gama; Sara Meirinho; Patrícia C. Pires; Johann Tinoco; Maria Carolina Martins Gaspar; Graça Baltazar; Gilberto Alves; Adriana O. Santos. "Simvastatin is delivered to the brain by high-strength intranasal cationic SMEDDS and nanoemulsions". Drug Delivery and Translational Research (2025) url
    2. Lima, Eurico; Ferreira, Octávio; Oliveira, João M.; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; Santos, Adriana O.; Reis, Lucinda V. "From darkness to radiance": Light-induced type I and II ROS-mediated apoptosis for anticancer effects of dansylpiperazine-bearing squaraine dyes". Bioorganic Chemistry (2025) url
    3. Ana Maia; Cathy Ventura; Adriana O. Santos; Maria J. Nunes; Renato E. F. Boto; Ângela Sousa; Samuel M. Silvestre; Paulo Almeida; João L. Serrano. "A New Demand for Improved Selectivity and Potency of Cyanine Dyes as Antiproliferative Agents Against Colorectal Cancer Cells". Molecules (2024) url
    4. Inês Afonso; Ana R. Neves; Dalinda Eusébio; Tânia Albuquerque; Eric Vivès; Prisca Boisguérin; Adriana O. Santos; Ângela Sousa; Diana Costa. "Design of Experiments to Tailor the Potential of BSA-Coated Peptide Nanocomplexes for Temozolomide/p53 Gene Co-Delivery". Pharmaceutics (2024) url
    5. Guedes, Romina A.; Grilo, Jorge H.; Carvalho, Andreia N.; Fernandes, Pedro M. P.; Ressurreição, Ana S.; Brito, Vanessa; SANTOS, ADRIANA O.; et al. Autor correspondente: Guedes, Rita C. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals (2023) url

    Capítulo de livro/Book chapter

    1. Melo, Dora; Patrícia C. Pires; Santos, Adriana O. Autor Correspondente: Santos, Adriana O. "Intranasal administration of antiseizure drugs". In Drug Delivery Devices and Therapeutic Systems: Elsevier, 2020.
      Publicado
    2. Santos, Adriana; Moreira, J.N.; Bimbo, L.M.; Gomes Da Silva, L; Pedrososo De Lima, M. C.; Simões, S. "Gene silencing therapy in small cell lung cancer - which agents, targets, and delivery systems?". In In Small-Cell Carcinomas: Causes, Diagnosis, and Treatment editado por Jonathon G. Maldonado; Mikayla K. Cervantes, 1-50: Nova Science, 2009.
      Publicado

    Patentes/Patents

    1. SELF-EMULSIFYING COMPOSITION, PRODUCTION METHODS AND USES THEREOF
      Número: PCT/IB2022/05538
      Proprietário: University of Beira Interior
      Estado: Pendente
      Data de Emissão: 2022-12-15

    Nota Biográfica


    (Informação importada da plataforma CiênciaVitae)
    Adriana O. Santos holds a degree in Pharmaceutical Sciences (2003) and a Ph.D. in Pharmacy (2009), specializing in Pharmaceutical Technology, from the University of Coimbra. Her doctoral thesis focused on targeted liposomes containing siRNA for the treatment of small cell lung cancer. Adriana was a postdoctoral researcher at Institut Curie in Paris (2009-2012), where she studied the intracellular signaling of Ral and RalGEFs in lung cancer cells. In 2012, Adriana O. Santos became Assistant Professor at the University of Beira Interior, Department of Medical Sciences, and a researcher at RISE-Health, UBI. Since 2015, Adriana has been a member of the scientific and pedagogical coordination committees of the Integrated Master’s Degree in Pharmaceutical Sciences and was recently appointed as its mobility coordinator. Adriana also coordinated the research group "Drug Discovery, Development, and Safety" (3DS) at CICS-UBI (2022-2024) and was a member of the research center’s executive committee Adriana has (co)supervised two Ph.D. theses: one in Pharmaceutical Sciences (UBI, March 2021) and another in Chemical and Biological Sciences (UTAD, October 2024). Additionally, she has (co)supervised 46 master''s dissertations and 6 undergraduate projects. Her current research primarily focuses on intranasal drug delivery targeting brain-related conditions and other formulation strategies to increase or improve drug delivery. Adriana O. Santos has co-authored 45 peer-reviewed articles, with 24 published since 2021. She has also contributed to 2 book chapters and over 80 communications at scientific conferences. Furthermore, she is listed as an inventor on a pending international patent Adriana was the principal investigator of the project Intranasal Delivery of Simvastatin in Stroke awarded the "CICS-UBI Collaborative Project Awards" in 2021 and the proof-of-concept project funded by PO Centro titled Segesterone Acetate Innovative Nanoemulsion (SAIN) and participated in over other 9 funded projects. She has participated in 5 doctoral examination boards —3 times as an examiner and 2 as a committee member—and in scientific committees of international meetings.

    Projectos e Financiamentos


    (Informação importada da plataforma CiênciaVitae)

    Bolsa

    Segesterone Acetate Innovative Nanoemulsion (SAIN) CENTRO-01-0145-FEDER-181231 (Em curso)
    CovidOUT - Spray to reduce the nasal transmiayion of coronavirus CENTRO-01-02B7-FEDER-069358 (Concluído)
    ICON - Interdisciplinary Challenges On Neurodegeneration CENTRO-01-0145-FEDER-000013 (Concluído)
    Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery PTDC/QEQ-MED/7042/2014 (Concluído)
    Deciphering the networks leading to the activation of the Ral GTPases in human lung cancers, dependently or not on Ras RS12/75-62

    Contactos

    aosðubi÷pt
    5079

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