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Cláudio Jorge Maia Baptista

Professor/a Auxiliar

Sector — Cargos/Funções

Departamento de Ciências Médicas Docente do Departamento de Ciências Médicas

CICS - Centro de Investigação em Ciências da Saúde Investigador/a

Diretor/a do(s) curso(s)

Publicações Científicas Mais Recentes

(Informação importada da plataforma CiênciaVitae)

    Artigo em revista/Journal article

    1. Rocha, S.M.; Nascimento, D.; Cardoso, A.M.; Passarinha, L.; Socorro, S.; Maia, C.J. "STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide". Molecular medicine reports (2023) url
    2. Sandra M. Rocha, Daniel Nascimento, Rafaella S. Coelho, Ana Margarida Cardoso, Luís Passarinha, Sílvia Socorro and Cláud. "STEAP1 Knockdown Decreases the Sensitivity of Prostate Cancer Cells to Paclitaxel, Docetaxel and Cabazitaxel". International Journal of Molecular Sciences (2023)
    3. Andreia P Alves; Sandra M Rocha; Ana C Mamede; Patrícia C Braga; Marco G Alves; Pedro F Oliveira; Filomena M Botelho; Cláudio J Maia. "Differential response of hepatocellular carcinoma glycolytic metabolism and oxidative stress markers after exposure to human amniotic membrane proteins". Molecular Biology Reports (2022) url
    4. Feiteiro, J.; Rocha, S.M.; Mariana, M.; Maia, C.J.; Cairrão, E. "Pathways involved in the human vascular Tetrabromobisphenol A response: Calcium and potassium channels and nitric oxide donors". Toxicology (2022) url
    5. J Barroca-Ferreira; AM Gonçalves; MFA Santos; T Santos-Silva; CJ Maia; LA Passarinha. "A chromatographic network for the purification of detergent-solubilized six-transmembrane epithelial antigen of the prostate 1 from Komagataella pastoris mini-bioreactor lysates". Journal of Chromatography A (2022) url

    Capítulo de livro/Book chapter

    1. Rocha, Sandra M; Barroca-Ferreira, Jorge; Passarinha, Luís A; Socorro, Sílvia; Maia, Cláudio J. "The Usefulness of STEAP Proteins in Prostate Cancer Clinical Practice". In Prostate Cancer, 139-154: Exon Publications, 2021.
    2. Rocha Sm; Maia, C J. "Biochemical Properties of Amniotic Membrane". In Amniotic Membrane: Origin, Characterization, and Medical Applications, NA-NA: Springer Netherlands, 2015.
    3. Gomes, I. M.; Vaz Cv; Rodrigues D; Rocha Sm; Santos, C. R.; Socorro S; Maia, C.J. "Estrogens and prostate cancer: from biosynthesis to physiological effects". In Estradiol synthesis: health effects and drug interactions, N.A.-N.A.: Nova Science Publishers, Inc, 2013.
    4. Vaz Cv; Alves M; Marques R.; Oliveira Pf; Maia Cj; Socorro S. "Glucose Uptake and Androgen Responsiveness of Prostate Cancer Cells". In Glucose Uptake: Regulation, Signaling Pathways and Health Implications, 193-214: Nova Science Publishers, Inc, 2013.

    Nota Biográfica

    (Informação importada da plataforma CiênciaVitae)
    Cláudio Maia is graduated in Biochemistry and PhD in Biomedicine. From 2009, he is Associated Professor and integrated researcher at Health Sciences Research Center (CICS-UBI). In addition, he is vice-coordinator of Hormones & Metabolism Group of CICS-UBI and is member of the body responsible for animal welfare (ORBEA) of UBI. As investigator, he has published 66 articles in peer-reviewed journals, and supervise(d)/co-supervise(d) 25 masters students and 10 PhD students. The main scientific focus includes to explore the cellular and molecular mechanisms underlying the male reproductive function and prostate cancer, as well as to evaluate the usefulness of novel biomarkers and to explore novel strategies of treatment. As know-how technical, it can be highlighted his expertise in cell culture and animal experiments, and in several assays to evaluate gene expression (qPCR, western blot, and immunohistochemistry), assays of cell viability, cell cycle, and apoptosis (MTS, Ki-67, Tunel, Caspase-3 activity, etc)Besides his role as professor and researcher, he was responsible to organize and implement a diagnostic test (qPCR) for COVID-19 in "Cova da Beira" region. Considering his expertise in molecular biology and his work as volunteer in Laboratory for COVID-19 diagnostic tests, he is at the moment the Principal Investigator of the project "CICS4COVID - Test, Track, and innovate in the diagnosis of COVID-19 (AAC 02/SAICT/2020, nº 072541, ~300.000 euros)", funded by Fundo Europeu de Desenvolvimento Regional (FEDER) through the Programa Operacional Regional do Centro, and by Foundation for Science and Technology. Regarding his main focus of investigation, the ongoing projects intend to: i) characterize the role and regulation of Six Transmembrane Epithelial of the Prostate 1 (STEAP1) proteins in prostate cancer; ii) evaluate the usefulness of STEAP1 as a biomarker or putative therapeutic target; and iii)- explore novel approaches for the treatment of prostate cancer. Currently, he is member of the project "Structural Determination and Function Analysis of the STEAP1 Protein: Towards a New Target for Cancer Treatment Investigador", funded by Instruct-ERIC (PID: 11936).

    Distinções e Prémios

    (Informação importada da plataforma CiênciaVitae)
    2018Best "tutor" award in the first year of Medicine Integrated Master; Elected by students
    2017Best "Bloco-Cell Biology" award in the first year of Medicine Integrated Master; Elected by students
    2016Best "Bloco-Cell Biology" award in the first year of Medicine Integrated Master; Elected by students
    2014Best "tutor" award in the first year of Medicine Integrated Master; Elected by students
    2012Best poster presentation award in "V jornadas sobre tecnologia e saúde" - Instituto Politécnico da Guarda, Guarda, Guarda, Portugal
    2003School award for completing a Biochemistry degree with the best final grade - Universidade da Beira Interior, Covilhã, Castelo Branco, Portugal
    2003PhD Fellow - Fundação para a Ciência e a Tecnologia, Lisboa, Lisboa, Portugal

    Projectos e Financiamentos

    (Informação importada da plataforma CiênciaVitae)


    • Novel genes differentially expressed in breast and prostate cancer: effect of sex steroid hormones BD/13388/2003 2003 - 2007/11/ ()


    • Extrinsic factors in the modulation of prostate metabolism: applications in cancer prevention, diagnosis and treatment DGAV  - 2024// (Em curso)
    • Structural Determination and Function Analysis of the STEAP1 Protein: Towards a New Target for Cancer Treatment Instruct-ERIC, PID: 11936 2021 - 2022// (Em curso)


    • Shaping prostate cell metabolism by extrinsic factors: insights into cancer prevention, diagnosis and treatment POCI-01-0145-FEDER-029114 2018 - 2021// ()
    • Hormonal and Inflammatory basis of age-related diseases CENTRO-07-ST24-FEDER-002015 2013 - 2015// (Concluído)
    • Biosynthesis, purification and biointeraction of human soluble catechol-O-methyltransferase with Parkinson´s inhibitors 128284 2013 - 2014/5/ (Concluído)
    • Biosynthesis, purification and biointeraction of human soluble catechol-O-methyltransferase with Parkinson´s inhibitors Provided by PTCRIS: 128284 2013 - 2014/5/ (Concluído)
    • Amniotic membrane: a therapeutic option against cancer? CIMAGO 07/12 2012 - 2013// ()
    • C4- Cloud Computing Competence Centre. Research Line 2 Cloud Applications  WP 2.6 - Bioinformatics 2019 - // (Em curso)
    • CICS4COVID- Test, Track, and innovate in the diagnosis of COVID-19 02/SAICT/2020- 72541 2020 - // (Em curso)


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