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Comunicação Celular

Código 12829
Ano 3
Semestre S2
Créditos ECTS 6
Carga Horária PL(15H)/T(30H)/TP(15H)
Área Científica Bioquímica
Mode of delivery face-to-face
Work placements NA
Learning outcomes To understand the main processes of cellular communication and relate them to the coordination of physiological processes in organisms.
To know the main inter and intracellular messengers, how their levels are regulated and to understand their modes of action. Understanding the role of receptors.
At the end of course the student must be able to:
Explain the process of intercellular communication and identify the main intercellular mediators.
Relate the structure of a receptor with its function. Deducing its saturation curve.
Identify and interrelate the main intracellular signaling pathways activated by different types of receptors.
Explain how the different signaling pathways are integrate in the coordination of cellular activity and physiological processes.
To know how to assess experimentally the effect of extracellular mediators in the formation of 2nd messengers.
Analyze a scientific paper, synthesize its information and present it to colleagues.
Syllabus Theoretical classes:
1. Cell communication: general principles.
2. Intercellular communication. Extracellular signals.
3. Receptors.
4. Intracellular signalling.
5. Experimental techniques used in the study of cell communication.
6. G protein-coupled Receptors.
6.1. G protein modulated enzymes. Adenylyl cyclase. Phospholipase C.
6.2. Receptor-regulated ion channels.
7. Ca2+ as an intracellular messenger.
8. Receptors with enzyme activity.
8.1. Guanylyl cyclases.
8.2. Tyrosine kinase receptors. PLC-gamma, Ras/MAPK and PI3-K/PKB signaling pathways.
8.3. Serine/threonine kinase receptors.
9. Signalling through adhesion molecules.
10. Notch/Delta, Wnt and Hedgehog signalling pathways.
13. Neurotransmission.
14. The cell cycle. Apoptosis.

Practical classes:
Theoretical-practical work involving extracellular mediator-stimulated 2nd messenger quantitation.
Solving of exercises.
Presentation and discussion by the student of a scientific paper.
Main Bibliography [1] Gomperts, B.D., Kramer, I.M., & Tatham, P.E.R. (2009) – Signal Transduction. 2nd ed. Elsevier Academic Press.
[2] Hancock, J.T. (2005) – Cell Signalling. 2nd ed. Oxford University Press.
[3] Lodish, H., Berk, A., Matsudaira, P., Kaiser, C.A., Krieger, M., Scott, M.P., Zipursky, S.L. & Darnell, J. (2004) – Molecular Cell Biology. 5th ed. W.H. Freeman and Company.
[4] D. Voet & Voet, J. (2004) – Biochemistry. 3rd ed. Wiley.
[5] Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. & Watson, J.D. (1994) – Molecular Biology of the Cell. 3rd ed. Garland Publishing.
Language Portuguese. Tutorial support is available in English.

Regente

Imagem d@ José Francisco da Silva Cascalheira [Ficheiro Local]
 José Francisco da Silva Cascalheira

Curso

Bioquímica
Data da última atualização: 2025-03-27
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