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Química Orgânica Farmacêutica

Código 12835
Ano 3
Semestre S2
Créditos ECTS 6
Carga Horária PL(30H)/T(30H)
Área Científica Bioquímica
Mode of delivery Presence with e-learning
Learning outcomes Complementary studies in Organic Chemistry.
Use the concept of protecting group.
Analyze the heterocyclic compounds.
Apply the concepts of retrosynthesis.
Acquire knowledge about the molecular basis of the discovery, design, development and action of drugs.
Realize that it is possible perform certain reactions using protecting groups.
Knowing the methods of analysis of molecules from the target molecule and able to search for the simpler molecules for the synthesis.
Identify the different heterocyclic compounds.
Apply current strategies for the discovery and development of leads.
Predict the effects of the chemical characteristics of drugs in their pharmacokinetics.
Evaluate and interpret structure-activity relationships.
Predict drug interactions with biological targets and the molecular mechanisms underlying.
Syllabus Theorical classes
Chapter 1 PHENOLS
Chapter 2 AMINES AND DERIVATIVES
Chapter 3 PROTECTING GROUPS
Chapter 4 RETROSYNTHESIS
Chapter 5 HETEROCYCLIC COMPOUNDS
Aromatics
Non aromatic compound
Chapter 6 INTRODUCTION TO PHARMACEUTICAL CHEMISTRY
Chapter 7 DRUG DISCOVERY, DESIGN AND DEVELOPMENT
Lead discovery and modification
Qualitative and quantitative structure-activity relationships
Computer-assisted drug-design
Prodrugs
Chapter 8 DRUG INTERACTION WITH RECEPTORS
Chapter 9 DRUG INTERACTION WITH ENZYMES
Laboratory classes
1 Introduction
2 Reactions of protection of functional groups
3 Electrophilic aromatic substitution reactions
4 Preparation of heterocyclic compounds (2 classes)
5 Problems classes (2 classes)
6 Identification and quantification of drugs (3 classes)
7 Stereoselective reactions
8 Gastrointestinal absorption of drugs and preparation of prodrugs (2 classes)
9 Discussion of reports (2 classes)
Teaching Methodologies and Assessment Criteria -
Main Bibliography 1. T. W. G. Solomons, G. B. Fryhle, Organic Chemistry, 9th Ed., J. Wiley & Sons, Inc., USA, 2008.
2. F. A. Carey, Organic Chemistry, 6th Ed., Mc Graw Hill, N. Y., 2006.
3. T. W. Greene, P. G. M. Wuts, Protective Groups in Organic Synthesis, 3rd Ed., J. Wiley & Sons, Inc., USA, 1999.
4. R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd Ed., Elsevier Academic Press, 2004;
5. G. L. Patrick, An Introduction to Medicinal Chemistry, 4th Ed., Oxford University Press, 2010;
6. C. Avendaño, Introductión a la Química Farmacéutica, 2ª Ed., Mc.Graw-Hill, 2001;
7. http://old.iupac.org/publications/cd/medicinal_chemistry/
Language Portuguese. Tutorial support is available in English.

Regente

Imagem d@ José Albertino Almeida de Figueiredo [Ficheiro Local]
 José Albertino Almeida de Figueiredo

Curso

Bioquímica
Data da última atualização: 2022-03-14
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