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Cândida Ascensão Teixeira Tomaz

Professor/a Associado/a

Sector — Cargos/Funções

Instituto Coordenador da Investigação - ICI Presidente do Instituto Coordenador de Investigação

Departamento de Química Docente do Departamento de Química

CICS - Centro de Investigação em Ciências da Saúde Investigador/a

Diretor/a do(s) curso(s)

Publicações Científicas Mais Recentes


(Informação importada da plataforma CiênciaVitae)

    Artigo em conferência/Conference paper

    1. Fátima Milhano dos Santos; Gaspar, Leonor M.; Albuquerque, Tânia Gonçalves; João ML Dias; João Paulo Castro de Sousa; Alberto Paradela; Tomaz, Cândida; Passarinha, Luí. "Improvement of bidimensional electrophoretic conditions for vitreous protein analysis using an artificial neural network.". 2018.
    2. Mesquita, Joana; Castro de Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative research of VEGF-A, VEGF-B and PIGF in vitreous and serum in angiogenic ocular disorders". 2018.
      Publicado
    3. Mesquita, Joana; Castro e Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative analysis and correlation of VEGF-A and VEGF-B in serum and vitreous humor of patients with proliferative vs non-proliferative ocular disease". 2017.
      Publicado
    4. Mesquita, Joana; Castro Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Tavares-Ratado, Paulo; Passarinha, Luis; Tomaz, Candida. "Correlation between concentration of vitreous angiogenic cytokines (VEGF-B and PIGF) with central retinal thickness and macular volume in diabetic retinopathy patients". 2016.
      Publicado
    5. Mesquita, Joana; Castro Sousa, Joao Paulo; Tavares-Ratado, Paulo; Vaz-Pereira, Sara; Neves, Arminda; Rocha, Ana S.; Santos, Fatima; Passarinha, Luis; Tomaz, Candida. "Comparison of serum and vitreous PIGF in diabetic retinopathy patients and nondiabetic patients". 2015.

    Artigo em revista/Journal article

    1. Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; Pereira de Almeida, Luí; Campello, Maria Paula Cabral; et al. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules (2024) url
    2. Mesquita, Joana; Santos, Fátima Milhano; Sousa, João Paulo; Vaz-Pereira, Sara; Tavares-Ratado, Paulo; Neves, Arminda; Mesquita, Rita; Tomaz, C. T. Autor correspondente: Tomaz, C. T. "Serum and Vitreous Levels of Placenta Growth Factor in Diabetic Retinopathy Patients: Correlation With Disease Severity and Optical Coherence Tomographic Parameters". Cureus (2024) url
    3. Moreira, David; Alexandre, Daniela; Miranda, André; Lourenço, Pedro; Baptista, Pedro V.; Tomaz, Cândida; Lu, Yi; Cruz, Carla. "Detecting mir-155-3p through a Molecular Beacon Bead-Based Assay". Molecules (2024) url
    4. Ribeiro, João; Luí, Marco Â.; Rodrigues, Bruno; Santos, Fátima Milhano; Mesquita, Joana; Boto, Renato; Tomaz, C. T. Autor correspondente: Tomaz, C. T. "Cryogels and Monoliths: Promising Tools for Chromatographic Purification of Nucleic Acids". Gels (2024) url
    5. David Moreira; Jéssica Lopes-Nunes; Fátima Milhano Santos; Maria Paula Cabral Campello; Maria Cristina Oliveira; António Paulo; Cândida Tomaz; Carla Cruz. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals (2023) url

    Capítulo de livro/Book chapter

    1. Tomaz, C. T.; A. Mendonça; Vapor, Alcides. Autor Correspondente: Tomaz, C. T. "Effect of food processing on allergenicity of egg proteins.". In Food Allergies: Processing Technologies for Allergenicity Reduction: CRC Press, 2024.
      Publicado
    2. Tomaz, C. T.; Fátima Milhano Dos Santos; Mesquita, Joana. "Regulation of Intraocular Oxygen by the Vitreous Gel.". In Encyclopedia of the Eye: Elsevier, 2024.
      No prelo
    3. Tomaz, Cândida T. "Hydrophobic interaction chromatography *". In Liquid Chromatography: Fundamentals and Instrumentation, Handbooks in Separation Science, 171-190: Elsevier, 2017.
      Publicado
    4. Caramelo-Nunes, Catarina; Tomaz, Cândida T. "Specific Recognition of Supercoiled Plasmid DNA by Affinity Chromatography Using a Synthetic Aromatic Ligand". In Methods in Molecular Biology: Affinity Chromatography Methods and Protocols editado por Senta Reichelt, 47-54: Springer New York, 2015.
      Publicado
    5. C. Peixinho, P Tavares-Ratado, M. Gabriel, A. Romeira, C. Lozoya-Ibanez, L. Taborda-Barata, C.T. Tomaz, C. "Different in vivo reactivity profile in health care workers and patients with spina bifida to internal and external latex glove surface-derived allergen extracts". In World Biomedical Frontiers , Allergy: BENTHAM SCIENCE PUBLISHERS, 2013.

    Nota Biográfica


    (Informação importada da plataforma CiênciaVitae)
    Cândida Tomaz holds a PhD in Biochemistry (2002, University of Beira Interior - UBI) and a degree in Pharmaceutical Sciences (1990, University of Coimbra). She is currently Associate Professor in the Department of Chemistry, Faculty of Sciences, at UBI, where she has coordinated the Biochemistry Doctoral Program since 2013 and has also served for several years as Director of the 1st and 2nd Cycle Degrees in Biochemistry. She serves as President of the Coordinator Institute of Research (ICI-UBI) and has previously been President of both the Faculty Council and the Pedagogical Council of the Faculty of Sciences, as well as a member of the University General CouncilShe was Vice-Coordinator of the Biopharmaceuticals and Biomaterials Research Group and a member of the Executive Board of the Health Sciences Research Centre (CICS-UBI). Since 2025, she has been an integrated researcher at RISE-Health, the newly created and largest R&D unit in Portugal. Her research focuses on downstream processing and purification of biopharmaceuticals, particularly the development of novel chromatographic supports such as monoliths and cryogels. She is also involved in developing innovative therapeutic strategies for ocular neovascular diseases. C. Tomaz has participated in 23 national and international research projects, including six as principal investigator, two funded by Novartis Farma and one awarded by the Portuguese Pharmaceutical Society (Ordem dos Farmacêuticos). She collaborates with several institutions, including the University of the Basque Country (Lascaray Research Centre), the National Biotechnology Centre (CSIC, Madrid), the University of Coimbra, the University of Minho, and multiple hospitals (CHUCB, HUC, ULS Guarda, CH Leiria). She has supervised around 50 MSc and 8 PhD theses, and is currently supervising or co-supervising 2 PhD and 2 MSc students. Her scientific output includes approximately 60 peer-reviewed papers, 9 book chapters, over 1,450 citations, and an h-index of 20. Her main research keywords are: Chromatography, Plasmid DNA, DNA Vaccines, Aptamers, Proteomics, Cryogels, Monoliths, Biological Engineering, Retinal Diseases, Phenolic Compounds, and Bioprocesses.

    Distinções e Prémios


    (Informação importada da plataforma CiênciaVitae)
    Prémio
    2021BInov 2021 Award, Innovation Scholarship - Order of Pharmacists, Lisbon, Lisbon, Portugal
    2019Best Poster Presentation - XX EuroFoodChem Conference, Porto, Porto, Portugal
    2014Best Poster Presentation - European Academy of Allergy and Clinical Immunology, Zurich, Suiça
    2013Best Scientific Abstract - European Academy of Allergy and Clinical Immunology, Zurich, Suiça
    2012Best Oral Communication - Portuguese Society of Medical Hydrology, Monchique, Monchique, Portugal
    Outra distinção
    2011Best Poster
    2010Best Poster

    Prémios Recebidos

    Projectos e Financiamentos


    (Informação importada da plataforma CiênciaVitae)

    Bolsa

    CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIsease: wheN two are bettEr than one BINOV 2021 (Concluído)
    Proteomic and Metabolomic Analysis of Vitreous Humor in Vitreoretinal Diseases Ref.14- C4 Cloud Computing (Concluído)

    Projeto

    Vaginal gel for topical application in precancerous lesions caused by the HPV CENTRO-45-2021-30 (Em curso)
    CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIseases UIDP/Multi/00709/2020 (Concluído)
    CheckImmune Project 251_596879301 (Em curso)

    Mais Info

    Principais áreas de interesse científico:

    • Biotecnologia: Produção e Purificação de Biomoléculas /Processos cromatográficos (Cromatografia de Interacção hidrofóbica, Cromatografia de afinidade)
    • Bioquímica Clínica/ Autoimunidade/ Imunologia

    Publicações

    Publicações mais relevantes:

    • C.T. Tomaz e J.A. Queiroz, “Studies on Chromatographic Fractionation of Trichoderma reesei Cellulases by Hydrophobic Interaction Chromatography”, Journal of Chromatography. A, 865, 123-128, 1999.
    • J.A. Queiroz, C.T. Tomaz e J..M.S. Cabral “Hydrophobic Interaction Chromatography of Proteins”, Journal of Biotechnology, 87, 143-159, 2001.
    • C.T. Tomaz, D. Duarte e J.A. Queiroz, “Comparative Study for Cellulases Fractionation on Some Hydrophobic Interaction Chromatography Adsorbents”, Journal of Chromatography A, 944, 211-216, 2002.
    • C.T. Tomaz, A. Rocha e J.A. Queiroz, “Hydrophobic Interaction Chromatography of Trichoderma reesei Cellulases on Polypropylene Glycol-Sepharose”, Separation Science and Technology, 37, 1641-1651, 2002.
    • C.T. Tomaz e J.A. Queiroz “Fractionation of Trichoderma reesei Cellulases by Hydrophobic Interaction Chromatography on Phenyl-Sepharose”, Biotechnology Letters, 26, 223-227, 2004.
    • F. Sousa, C. T. Tomaz, D. M. F. Prazeres, J. A. Queiroz, “Separation of supercoiled and open circular plasmid DNA isoforms by chromatography with a histidine-agarose support” Analytical Biochemistry, 343, 183-185, 2005.
    • C. Peixinho, P. Tavares-Ratado, M.R. Tomaz, L. Taborda-Barata, C.T. Tomaz "Differential Expression of Allergens on Internal and External Surfaces of Latex Surgical Gloves: a Key to Explain Sensitization Routes in Different Risk Groups" Allergol. Immunopathol., 34 (5), 206-211, 2006.
    • C. Peixinho, P. Tavares-Ratado, M.R. Tomaz, L. Taborda-Barata, C.T. Tomaz “Latex Gloves: new insights to explain different sensitization profiles in different risk groups” British Journal of Dermatology, 159 (1), 132-136, 2008.
    • P. Fonseca, P. Tavares-Ratado, C. T. Tomaz "Interference of Dermatophagoides’ specific IgG in the quantification of mite’s specific IgE" Journal of Immunoassay and Immunochemistry, 30, 338-347, 2009.
    • A. Silva, R. E. F. Boto, C. T. Tomaz, J. A. Queiroz, P. Almeida “Rhodamine B as Ligand for Affinity Chromatography. Chromatographic Studies on Derivatized Beaded Cellulose” Journal of Chromatographic Science, 48, 240-244, 2010.
    • C. Amaral, E. Gallardo, R. Rodrigues, R. Pinto Leite, D. Quelhas, C. Tomaz, M.L. Cardoso “Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects” Journal of Chromatography B (doi:10.1016/j.jchromb.2010.06.010).

    Contactos

    Email: ctomazðubi÷pt
    Telefone: 275319762
    Extensão: 1456
    Extensão: 5018

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