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Cândida Ascensão Teixeira Tomaz

Professor/a Associado/a

Sector — Cargos/Funções

Departamento de Química Docente do Departamento de Química

CICS - Centro de Investigação em Ciências da Saúde Investigador/a

Diretor/a do(s) curso(s)

Publicações Científicas Mais Recentes

(Informação importada da plataforma CiênciaVitae)

    Artigo em conferência/Conference paper

    1. Fátima Milhano dos Santos; Gaspar, Leonor M.; Albuquerque, Tânia Gonçalves; João ML Dias; João Paulo Castro de Sousa; Alberto Paradela; Tomaz, Cândida; Passarinha, Luí. "Improvement of bidimensional electrophoretic conditions for vitreous protein analysis using an artificial neural network.". 2018.
    2. Mesquita, Joana; Castro de Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative research of VEGF-A, VEGF-B and PIGF in vitreous and serum in angiogenic ocular disorders". 2018.
    3. Mesquita, Joana; Castro e Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative analysis and correlation of VEGF-A and VEGF-B in serum and vitreous humor of patients with proliferative vs non-proliferative ocular disease". 2017.
    4. Mesquita, Joana; Castro Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Tavares-Ratado, Paulo; Passarinha, Luis; Tomaz, Candida. "Correlation between concentration of vitreous angiogenic cytokines (VEGF-B and PIGF) with central retinal thickness and macular volume in diabetic retinopathy patients". 2016.
    5. Mesquita, Joana; Castro Sousa, Joao Paulo; Tavares-Ratado, Paulo; Vaz-Pereira, Sara; Neves, Arminda; Rocha, Ana S.; Santos, Fatima; Passarinha, Luis; Tomaz, Candida. "Comparison of serum and vitreous PIGF in diabetic retinopathy patients and nondiabetic patients". 2015.

    Artigo em revista/Journal article

    1. Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; Pereira de Almeida, Luí; Campello, Maria Paula Cabral; et al. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules (2024) url
    2. David Moreira; Jéssica Lopes-Nunes; Fátima Milhano Santos; Maria Paula Cabral Campello; Maria Cristina Oliveira; António Paulo; Cândida Tomaz; Carla Cruz. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals (2023) url
    3. Martins, Sílvia; António, Natália; Carvalheiro, Tiago; Laranjeira, Paula; Rodrigues, Ricardo; Gonçalves, Lino; Tomaz, Cândida; Paiva, Artur. "Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy". BMC Cardiovascular Disorders (2023) url
    4. Santos, Fátima M.; Ciordia, Sergio; Mesquita, Joana; Cruz, Carla; Sousa, João Paulo Castro e; Passarinha, LuísA.; Tomaz, Cândida T.; Paradela, Alberto. "Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases". Frontiers in Immunology (2023) url
    5. Sílvia Martins; Natália António; Ricardo Rodrigues; Tiago Carvalheiro; Cândida Tomaz; Lino Gonçalves; Artur Paiva. "Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy". BMC Cardiovascular Disorders (2023) url

    Capítulo de livro/Book chapter

    1. Tomaz, C. T.; Fátima Milhano Dos Santos; Mesquita, Joana. "Regulation of Intraocular Oxygen by the Vitreous Gel.". In Encyclopedia of the Eye: Elsevier, 2024.
      No prelo
    2. Tomaz, Cândida T. "Hydrophobic interaction chromatography *". In Liquid Chromatography: Fundamentals and Instrumentation, Handbooks in Separation Science, 171-190: Elsevier, 2017.
    3. Caramelo-Nunes, Catarina; Tomaz, Cândida T. "Specific Recognition of Supercoiled Plasmid DNA by Affinity Chromatography Using a Synthetic Aromatic Ligand". In Methods in Molecular Biology: Affinity Chromatography Methods and Protocols editado por Senta Reichelt, 47-54: Springer New York, 2015.
    4. C. Peixinho, P Tavares-Ratado, M. Gabriel, A. Romeira, C. Lozoya-Ibanez, L. Taborda-Barata, C.T. Tomaz, C. "Different in vivo reactivity profile in health care workers and patients with spina bifida to internal and external latex glove surface-derived allergen extracts". In World Biomedical Frontiers , Allergy: BENTHAM SCIENCE PUBLISHERS, 2013.
    5. Tomaz, C.T.; Queiroz, J.A. "Hydrophobic Interaction Chromatography". In Liquid Chromatography: Fundamentals and Instrumentation. editado por S. Fanali, P. Haddad, D. K. Lloyd, C.F. Poole, P.J, 121-141: Elsevier, 2013.

    Nota Biográfica

    (Informação importada da plataforma CiênciaVitae)
    Cândida Tomaz graduated in Pharmaceutical Sciences (1990) by University of Coimbra, Portugal, and completed her PhD in Biochemistry (2002) at University of Beira Interior (UBI). In 1990, she started her academic activities as Junior Teaching Assistant and since 2011 is holding the position of Associate Professor in the Chemistry Department of the Faculty of Sciences at UBI. Throughout her academic career C Tomaz has held several positions at UBI, including member of the General Council of the University, President of Sciences Faculty Council, President of Sciences Faculty Pedagogical Council and participation as a member of Coordinator Institute of Research of UBI. Additionally, she was also Vice-coordinator of Biopharmaceutical and Biomaterials Research Group and as an Executive Board member of Health Sciences Research Centre (CICS- UBI). Cândida Tomaz has plssed a pivotal role in education, having been the Course Director of the 1st and 2nd Cycles in Biochemistry and presently serving as the Coordinator of the Biochemistry Doctoral Program at UBIOver the years, she has supervised almost 50 MSc and 7 PhD theses, and currently, she is supervising or co-supervising 4 PhD and 2 MSc dissertation. C Tomaz published about 60 papers in international peer reviewed journals and 8 book chapters, accumulating approximately 1200 citations. In her professional activities interacted with 243 collaborator(s) co-authorship of scientific papers. She has published in specialized and multidisciplinary high-impact scientific journals, she also serves as a member of editorial reviewer boards. In collaboration with international institutions, such as Lascaray Research Centre, University of the Basque Country and National Biotechnology Center (CSIC) at Madrid, and also with several national partners, like the University of Coimbra, University of Minho, Coimbra Institute for Clinical and Biomedical Research, and several hospitals (CHUCB, HUC, ULS Guarda, CH Leiria), Cândida Tomaz has participated in 21 research projects, mostly in the Health Biotechnology field. She served as the principal investigator in 6 projects, with 2 funded by Novartis Farma and 1 awarded by Ordem dos FarmacêuticosHer research focus lies in downstream processing for the purification of biopharmaceuticals, particularly in the development of novel chromatographic supports, including monoliths and cryogels. Currently, she is also involved in a project aimed at developing innovative strategies for the treatment of ocular neovascular diseases. The most frequent terms in the context of scientific, technological and artistic-cultural output are: Chromatography; Plasmid DNA; DNA Vaccines; Aptamers; Proteomics; Cryogels; Monoliths; Biological Engineering and Biotechnology; Retinal Diseases; Phenolic Compounds; Egg allergy; Interactions and Bioprocess.

    Distinções e Prémios

    (Informação importada da plataforma CiênciaVitae)
    2021BInov 2021 Award, Innovation Scholarship - Order of Pharmacists, Lisbon, Lisbon, Portugal
    2019Best Poster Presentation - XX EuroFoodChem Conference, Porto, Porto, Portugal
    2014Best Poster Presentation - European Academy of Allergy and Clinical Immunology, Zurich, Suiça
    2013Best Scientific Abstract - European Academy of Allergy and Clinical Immunology, Zurich, Suiça
    2012Best Oral Communication - Portuguese Society of Medical Hydrology, Monchique, Monchique, Portugal
    Outra distinção
    2011Best Poster
    2010Best Poster

    Prémios Recebidos

    Projectos e Financiamentos

    (Informação importada da plataforma CiênciaVitae)


    CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIsease: wheN two are bettEr than one BINOV 2021 (Concluído)
    Proteomic and Metabolomic Analysis of Vitreous Humor in Vitreoretinal Diseases Ref.14- C4 Cloud Computing (Concluído)


    Vaginal gel for topical application in precancerous lesions caused by the HPV CENTRO-45-2021-30 (Em curso)
    CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIseases UIDP/Multi/00709/2020 (Concluído)
    CheckImmune Project 251_596879301 (Em curso)

    Mais Info

    Principais áreas de interesse científico:

    • Biotecnologia: Produção e Purificação de Biomoléculas /Processos cromatográficos (Cromatografia de Interacção hidrofóbica, Cromatografia de afinidade)
    • Bioquímica Clínica/ Autoimunidade/ Imunologia


    Publicações mais relevantes:

    • C.T. Tomaz e J.A. Queiroz, “Studies on Chromatographic Fractionation of Trichoderma reesei Cellulases by Hydrophobic Interaction Chromatography”, Journal of Chromatography. A, 865, 123-128, 1999.
    • J.A. Queiroz, C.T. Tomaz e J..M.S. Cabral “Hydrophobic Interaction Chromatography of Proteins”, Journal of Biotechnology, 87, 143-159, 2001.
    • C.T. Tomaz, D. Duarte e J.A. Queiroz, “Comparative Study for Cellulases Fractionation on Some Hydrophobic Interaction Chromatography Adsorbents”, Journal of Chromatography A, 944, 211-216, 2002.
    • C.T. Tomaz, A. Rocha e J.A. Queiroz, “Hydrophobic Interaction Chromatography of Trichoderma reesei Cellulases on Polypropylene Glycol-Sepharose”, Separation Science and Technology, 37, 1641-1651, 2002.
    • C.T. Tomaz e J.A. Queiroz “Fractionation of Trichoderma reesei Cellulases by Hydrophobic Interaction Chromatography on Phenyl-Sepharose”, Biotechnology Letters, 26, 223-227, 2004.
    • F. Sousa, C. T. Tomaz, D. M. F. Prazeres, J. A. Queiroz, “Separation of supercoiled and open circular plasmid DNA isoforms by chromatography with a histidine-agarose support” Analytical Biochemistry, 343, 183-185, 2005.
    • C. Peixinho, P. Tavares-Ratado, M.R. Tomaz, L. Taborda-Barata, C.T. Tomaz "Differential Expression of Allergens on Internal and External Surfaces of Latex Surgical Gloves: a Key to Explain Sensitization Routes in Different Risk Groups" Allergol. Immunopathol., 34 (5), 206-211, 2006.
    • C. Peixinho, P. Tavares-Ratado, M.R. Tomaz, L. Taborda-Barata, C.T. Tomaz “Latex Gloves: new insights to explain different sensitization profiles in different risk groups” British Journal of Dermatology, 159 (1), 132-136, 2008.
    • P. Fonseca, P. Tavares-Ratado, C. T. Tomaz "Interference of Dermatophagoides’ specific IgG in the quantification of mite’s specific IgE" Journal of Immunoassay and Immunochemistry, 30, 338-347, 2009.
    • A. Silva, R. E. F. Boto, C. T. Tomaz, J. A. Queiroz, P. Almeida “Rhodamine B as Ligand for Affinity Chromatography. Chromatographic Studies on Derivatized Beaded Cellulose” Journal of Chromatographic Science, 48, 240-244, 2010.
    • C. Amaral, E. Gallardo, R. Rodrigues, R. Pinto Leite, D. Quelhas, C. Tomaz, M.L. Cardoso “Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects” Journal of Chromatography B (doi:10.1016/j.jchromb.2010.06.010).



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